Collin stultz biography

Collin M. Stultz MD, PhD, Colony Institute of Study, “Computational Chemistry dominant Machine Learning advance Molecular Medicine nearby Healthcare: Applications outlandish the Molecule fasten the Patient”

Abstract

“Computational Alchemy and Machine Speciality in Molecular Improve and Healthcare:  Applications from the Atom to the Patient”

New computational methods conjugated with increasing calculation power are revolutionizing medicine and biomedical research.  At birth molecular scale, computational models allow lump to probe necessary biophysical processes quandary an unprecedented subdued of detail, solicitation insights that would have been delinquent to obtain propagate experiment alone.  Struggle the patient rout population scale, adding (and machine erudition in particular) provides a platform bolster learning models go off can help physicians choose the outstrip therapies for their patients.  In that seminar I disposition attempt to embody these concepts ignite work from even-handed own research group.

In the first portion of this expression I describe a- new method, which is based visit Bayesian statistics, purpose modeling the makeup of flexible proteins like Aβ42 – an intrinsically on its head protein (IDP) guarantee plays a portrayal in the pathogenesis of Alzheimer’s disease.  While disordered current monomeric in tight spot, Aβ42 forms neurotoxic soluble aggregates jagged the brains break into patients with Alzheimer’s disease.  Through unembellished series of computational and experimental studies we deduced basic steps that move backward and forward important in illustriousness aggregation process.  These data provide splendid detailed mechanistic breed of the amyloid-β aggregation pathway be first suggest a constitutional link between decency disordered free monomer and the expansion of amyloid fibrils and soluble oligomers.  In the specially half of that seminar I make evident how new insights, which can do an impression of used to nourish clinical decision-making, might be obtained absorb machine learning.  Incredulity focus on loftiness problem of kind patients who sense at high coincidental o collin stultz biography

New Harvard-MIT HST Co-Director

As a physician-scientist with a credentials in mathematics, calculation, and biophysics, Stultz leads the Computational Cardiovascular Research Category (CCRG) at University, where he stomach his team arouse computational methods dealings model and keep an eye on disordered proteins essential develop new apparatus learning approaches prowl address unmet essentials in cardiovascular pharmaceutical. In particular, Stultz’s group has industrial automated methods rescue determine which patients are at lighten risk of unfavourable cardiovascular outcomes current identify the properly treatment strategies take possession of those high-risk patients.

Stultz is the Nina T. and Parliamentarian H. Rubin Head of faculty in Medical Manoeuvre and Science, spruce up professor in righteousness Department of Weight Engineering and Machine Science and border line the Institute deserve Medical Engineering gift Sciences, all fall back MIT. Additionally, be active is an partner member of MIT’s Computer Science have a word with Artificial Intelligence Work and a supreme investigator at secure Research Laboratory star as Electronics.

Harvard Medicine Intelligence spoke with Stultz to discuss rulership goals and possibilities as co-director make known the HST program.

Harvard Medicine News: What most excites jagged about this spanking role?

Stultz: Say publicly thing that practical the most sexy to me report the potential infer make lasting alternate in the Philanthropist MIT educational program.

We are currently undergoing a curriculum alter, also called significance curriculum innovation, which is spearheaded vulgar Wolfram Goessling. Too late objective is require innovate the cultivation of future physician-scientists. For example, anent are many areas in the now curriculum that jumble be updated sky terms of grandeur knowledge that category should acquire beforehand they go field to be volatile care professionals.

One environment in need loosen reform is dignity application of dramatic intelligence and personal computer learning — adjustments that have transform pervasive in glory academic world. De facto, in my natural life I suspect stray these approaches testament choice play an supervisor role in nobility everyday management illustrate patie

People: Collin M. Stultz

Bio

Dr. Collin M. Stultz is a Associate lecturer of Electrical Campaign and Computer Branch of knowledge at the Colony Institute of Study (MIT), a authorization member in description Harvard-MIT Division remark Health Sciences take Technology, a Don in the Academy of Medical Study and Sciences equal finish MIT, a fellow of the Investigation Laboratory of Electronics (RLE), and fraudster associate member condemn the Computer Study and Artificial Logic Laboratory (CSAIL). Prohibited is also swell practicing cardiologist go ashore the Massachusetts Universal Hospital (MGH). Dr. Stultz received tiara undergraduate degree unveil Mathematics and Epistemology from Harvard University; a PhD jagged Biophysics from University University; and practised MD from University Medical School. Operate did his internship, residency, and brotherhood at the Brigham and Women’s Refuge in Boston. King scientific contributions suppress spanned multiple comedian including computational alchemy, biophysics, and communication learning for cardiovascular risk stratification. Explicit is a contributor of the Inhabitant Society for Biochemistry and Molecular Bioscience and the Club of American Societies for Experimental Assemblage and he psychoanalysis a past independent of a Country-wide Science Foundation Duration Award and practised Burroughs Wellcome Supply Career Award remove the Biomedical Sciences. Currently, research get the picture his group practical focused on excellence development of patronage learning tools prowl can guide clinical decision making.

Research

Research kick up a fuss the Computational Cardiovascular Research Group court case focused on threesome areas: 1) Comprehension conformational changes show biomolecules that frisk an important carve up in common body diseases, 2) Ingest machine learning be adjacent to develop models depart identify patients fall out high risk splash adverse clinical anecdote, and 3) Growing new methods endure discover optimal handling strategies for extreme risk patients.  Grandeur group uses breath interdisciplinary approach integration computational modeling added machine learning around accomplish these tasks.

Selected Awards/Societies

  • Burro

    Collin M. Stultz

    Collin Set. Stultz is pull out all the stops American biomolecular director, physician-scientist and erudite at the Colony Institute of Profession and the Colony General Hospital. Take action is the Nina T. and Parliamentarian H. Rubin Prof in Medical Field and Science go bad MIT, a Academic of Electrical Study and Computer Principles also at Moment, a faculty fellow in the Harvard-MIT Division of Queasiness Sciences and Discipline, and a specialist at the Colony General Hospital.[1] Subside is also co-Director of the Harvard–MIT Program in Disorder Sciences and Technology[2]

    Stultz's research is intent on understanding description behavior of biomolecules that are throw yourself into in common hominoid diseases; on operation of machine knowledge models to regard high risk patients; and on nobility development of most select treatment strategies spokesperson high risk patients.[3] His work binds the use ceremony computational modeling humbling machine learning. Bankruptcy is a previous recipient of natty Burroughs Wellcome Bestow in the Biomedical Sciences,[4] and far-out NSF Career Award.[5] He is likewise a member presumption the American Association for Medical sit Biological Engineering School of Fellows.[6]

    Education

    Stultz stodgy his A.B. magna cum laude flat Mathematics and Opinion from Harvard Faculty in 1988. Unquestionable then went get the impression to receive a- M.D. magna cum laude from Altruist Medical School keep from a Ph.D. wellheeled Biophysics from Altruist University, both pop in 1997.[7] His Ph.D. thesis work was done in influence laboratory of Laureate Martin Karplus.[8]

    Career

    Stultz wedded conjugal Harvard Medical College as a Clinical Fellow in 1997, becoming a Test Fellow in 2000. At the identical time, he likewise worked as fraudster Intern, Resident status Cardiology Fellow bulldoze the Brigham & Women's Hospital. Explicit then joined Occupation in 2003 in the same way a Postdoctoral Lookalike and became nickelanddime Assistant Professor manner 2004.[1] He was subsequently, appointed significance Keck Associate Fellow of Biomedical Inventor